Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

Accompanying website: https://depmap.org/R2-D2/

• James M. McFarland
• Zandra V. Ho
• Guillaume Kugener
• Joshua M. Dempster
• Phillip G. Montgomery
• Jordan G. Bryan
• John M. Krill-Burger
• Thomas M. Green
• Francisca Vazquez
• Jesse S. Boehm
• Todd R. Golub
• William C. Hahn
• David E. Root
• Aviad Tsherniak

Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

Accompanying website: https://depmap.org/ceres/

• Robin M. Meyers
• Jordan G. Bryan
• James M. McFarland
• Barbara A. Weir
• Ann E. Sizemore
• Han Xu
• Neekesh V. Dharia
• Phillip G. Montgomery
• Glenn S. Cowley
• Sasha Pantel
• Amy Goodale
• Yenarae Lee
• Levi D. Ali
• Guozhi Jiang
• Rakela Lubonja
• William F. Harrington
• Matthew Strickland
• Ting Wu
• Derek C. Hawes
• Victor A. Zhivich
• Meghan R. Wyatt
• Zohra Kalani
• Jaime J. Chang
• Michael Okamoto
• Todd R. Golub
• Jesse S. Boehm
• Francisca Vazquez
• David E. Root
• William C. Hahn
• Aviad Tsherniak

Defining a Cancer Dependency Map

Accompanying website: https://depmap.org/rnai

• Aviad Tsherniak
• Francisca Vazquez
• Phil G. Montgomery
• Barbara A. Weir
• Gregory Kryukov
• Glenn S. Cowley
• Stanley Gill
• William F. Harrington
• Sasha Pantel
• John M. Krill-Burger
• Robin M. Meyers
• Levi Ali
• Amy Goodale
• Yenarae Lee
• Guozhi Jiang
• Jessica Hsiao
• William F.J. Gerath
• Sara Howell
• Erin Merkel
• Mahmoud Ghandi
• Levi A. Garraway
• David E. Root
• Todd R. Golub
• Jesse S. Boehm
• William C. Hahn

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression

• Rosenbluh J
• Xu H
• Harrington W
• Gill S
• Wang X
• Vazquez F
• Root DE
• Tsherniak A
• Hahn WC

Genomic copy number dictates a gene-independent cell response to CRISPR-Cas9 targeting

• Andrew J. Aguirre
• Robin M. Meyers
• Barbara A. Weir
• Francisca Vazquez
• Cheng-Zhong Zhang
• Uri Ben-David
• April Cook
• Gavin Ha
• William F. Harrington
• Mihir B. Doshi
• Maria Kost-Alimova
• Stanley Gill
• Han Xu
• Levi D. Ali
• Guozhi Jiang
• Sasha Pantel
• Yenarae Lee
• Amy Goodale
• Andrew D. Cherniack
• Coyin Oh
• Gregory Kryukov
• Glenn S. Cowley
• Levi A. Garraway
• Kimberly Stegmaier
• Charles W. Roberts
• Todd R. Golub
• Matthew Meyerson
• David E. Root
• Aviad Tsherniak
• William C. Hahn

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

• Kryukov GV.
• Wilson FH.
• Ruth JR.
• Paulk J.
• Tsherniak A.
• Marlow SE.
• Vazquez F.
• Weir BA.
• Fitzgerald ME.
• Tanaka M.
• Bielski CM.
• Scott JM.
• Dennis C.
• Cowley GS.
• Boehm JS.
• Root DE.
• Golub TR.
• Clish CB.
• Bradner JE.
• Hahn WC.
• Garraway LA.

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

• Luc de Waal
• Timothy A Lewis
• Matthew G Rees
• Aviad Tsherniak
• Xiaoyun Wu
• Peter S Choi
• Lara Gechijian
• Christina Hartigan
• Patrick W Faloon
• Mark J Hickey
• Nicola Tolliday
• Steven A Carr
• Paul A Clemons
• Benito Munoz
• Bridget K Wagner
• Alykhan F Shamji
• Angela N Koehler
• Monica Schenone
• Alex B Burgin
• Stuart L Schreiber
• Heidi Greulich
• Matthew Meyerson

ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens

• Diane D. Shao
• Aviad Tsherniak
• Shuba Gopal
• Barbara A. Weir
• Pablo Tamayo
• Nicolas Stransky
• Steven E. Schumacher
• Travis I Zack
• Rameen Beroukhim
• Levi A. Garraway
• Adam A. Margolin
• David E. Root
• William C. Hahn
• Jill P. Mesirov